Gas6 molecular weight

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August undefined, 2024

Web1. Mass from volume & concentration Concentration: Formula Weight (daltons): Volume: Mass = 2. Volume from mass & concentration Mass: Formula Weight (daltons): Concentration: 3. Molarity from mass & volume Mass: Formula Weight (daltons): Volume: Molarity = 4. Dilute a stock solution Stock concentration: Desired concentration: Desired … WebDepositor: Clinical Proteomics Technologies for Cancer. Host Species: rabbit. Antigen Sequence: Positive Tested Species Reactivity: Human. Depositors Institution: National Cancer Institute. Antigen Molecular Weight: 98.3 kDa. Depositors Notes: AXLp is the receptor for growth factor GAS6. AXLp is also a host cell viral receptor.

Therapeutic aspects of the Axl/Gas6 molecular system

WebJan 18, 2024 · Published 18 Jan 2024 Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological activities are mediated by the interaction with three tyrosine kinase receptors: Tyro3, Axl, and MerTK, which are commonly and collectively abbreviated as TAM [ 4 ]. WebAnti-GAS6 Antibody detects endogenous levels of total GAS6 protein. Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein, that has a molecular weight of 75kDa. It is located on human chromosome 13q34. how to use the answer block in scratch

Baseline Plasma Gas6 Protein Elevation Predicts Adverse ... - Hindawi

WebJul 28, 2024 · Flow cytometry analysis of the indicated surface molecules on SKO-007(J3) pLKO.1-GAS6 shRNA or pLKO.1-Control (n=3). A representative experiment is shown (B, left panel). Histograms represent the MFI of specific mAb subtracted of MFI of isotype control. Data are shown as mean ± SD (*P< 0.05; Mann-Whitney) (B, right panel). Web康朗生物为您提供硫胺素酶thtpa抗体的参数及2024年最新报价，厂家专业的硫胺素酶thtpa抗体售后服务团队，是您值得信赖的 ... WebFeb 3, 2024 · Here, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors. orgill owner

Gas6/Axl Signaling Pathway in the Tumor Immune …

GAS6 (D3A3G) Rabbit mAb Cell Signaling Technology

WebMar 9, 2024 · These findings suggested that low expression of GAS6-AS1 might exert an essential role in AFST through downregulating its downstream target mRNAs GOLGA8A and BACH2, and GAS6-AS1 might be a potential target for AFST therapy. WebHuman Gas6 is a 75 kDa protein that shares 77%‑79% aa sequence identity with mouse and rat Gas6, and 43% aa identity with human protein S (over the region expressed). … how to use the anvil in hydroneerWebJan 11, 2006 · The crystal structure at 3.3 A resolution of a minimal human Gas6/Axl complex reveals an assembly of 2:2 stoichiometry, in which the two immunoglobulin-like domains of the Axl ectodomain are crosslinked by the first laminin G-like domain of Gas6, with no direct Axl/Axl or Gas6/Gas6 contacts. how to use the animator in unity

"WebNov 4, 2024 · Although full-length AXL contains 894 amino acids and encodes a predicted protein of 98 kDa, the actual observed molecular weight ranges from 100 to 140 kDa … " - Gas6 molecular weight

Gas6 molecular weight

WebMar 23, 2024 · Background knowledge of Gas6. Gas6 is a 75 kDa secreted protein with a Gla domain at the N terminus that, based on its structure, belongs to the VKD protein family. 10 The Gla domain is generated by VKD γ-carboxylation of a cluster of Glu residues and is believed to be involved in intramolecular and intermolecular protein–protein or … WebThe gene, designated gas6 by the authors, is expressed as an abundant 2.6-kb mRNA in starved cells but decreases significantly upon stimulation of cells with serum or fibroblast …

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WebSuitable for use as control antibody for Gas6 siRNA (h): sc-35450, Gas6 shRNA Plasmid (h): sc-35450-SH and Gas6 shRNA (h) Lentiviral Particles: sc-35450-V. Molecular Weight of Gas6: 85 kDa. Positive Controls: Gas6 (h): 293T Lysate: sc-115479, SH-SY5Y cell lysate: sc-3812 or SK-N-SH cell lysate: sc-2410. RECOMMENDED SUPPORT REAGENTS WebJan 18, 2024 · Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological …

WebFor experiments assaying the requirement for a GAS6 gradient, cells containing 200 ng/ml GAS6 in DMEM-H were placed in the upper well of the chamber (GAS6/U&L). Following … WebMar 8, 2024 · TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poor …

WebTaken together, our results identiﬁed GAS6-AS1 as a noveltumorsuppressorinLUAD andunraveleditsunderlying molecular mechanism in reprogramming glucose metabolism. GAS6-AS1 potentially may serve as a prognostic marker and therapeutic target in LUAD. INTRODUCTION WebJun 18, 2024 · Although the molecular weight of the full-length Axl is 104 kDa, post-translational modifications of the extracellular domains give rise to two modified forms with molecular weights 120 and 140 kDa. Potential N-linked glycosylation sites include Asn 43, Asn 157, Asn 198, Asn 339, Asn 345, and Asn 401 [ 15 ]. Figure 1.

WebMar 24, 2005 · Gas6 was demonstrated to be present in human plasma, at a concentration determined to be 13 to 23 ng/mL (0.16 to 0.28 nM). Furthermore, plasma Gas6 levels …

WebApr 10, 2024 · Activation of AXL Receptor and its ligand GAS6 is a major mechanism of acquired resistance to EGFR-TKIs therapy ... Moreover, due to its relatively large molecular weight, the concentration of drug in tumors is limited. Study suggested only a small portion of ADCs could reach to the tumor cells. how to use the anime filter on tiktokWebMar 23, 2024 · Gas6 is a 75 kDa secreted protein with a Gla domain at the N terminus that, based on its structure, belongs to the VKD protein family. 10 The Gla domain is generated by VKD γ -carboxylation of a... how to use the anker powercore 10000WebGas6 is present at around 0.2 nM (18 ng mL−1) in normal human serum or plasma [4], whereas the anticoagulant protein S is present at a thousand-fold higher concentration … how to use the anker powercore slim 10000WebDec 1, 2024 · Finally, Axl and Gas6 are a key molecular system exploited by flaviviruses, such as Ebola (EBV) or Zika (ZIKV) viruses 12, 13. The Axl/Gas6 system is also involved … orgill product search orgill project lead salaryWebApr 29, 2024 · Figure 1 shows the ROC curve referred to baseline Gas6 levels: considering an area under the curve of 0.653, we identified a Gas6 level of 58.0 ng/ml as the cut-off predicting a more severe disease evolution (53.33% sensitivity and 77.57% specificity), with a likelihood ratio of 2.38 (IQR: 1.46-3.87). Figure 1 how to use the anycubic mega pro 3d printerWebMar 23, 2024 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic … orgill park golf course millington tn