High affinity choline transporter 1-like

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August undefined, 2024

Web1 de out. de 2014 · A single nucleotide polymorphism (SNP) for human CHT1 has been identified, which has a replacement from isoleucine to valine in the third transmembrane segment and shows the choline uptake activity of 50-60% as much as that of wild-typeCHT1. This article summarizes molecular properties of the high-affinity choline … Web1 de jan. de 2024 · CHT1 has been functionally characterized by its capacity to transport choline with high affinity when expressed in cultured cells or Xenopus oocytes. CHT1 transports choline with a Km value of 1–5 μM in a Na + - and Cl −-dependent manner (Okuda et al. 2000).The only known specific inhibitor of CHT1 is hemicholinium-3 (HC-3), …

The high-affinity choline transporter: a critical protein for ...

WebThe high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It is a cell membrane … Web13 de abr. de 2024 · 1 Introduction. The primary inhibitory neurotransmitter in the mammalian central nervous system (CNS) is γ-aminobutyric acid (GABA). Its presence in the brain was discovered independently by three groups in the year 1950 (Awapara et al., 1950; Roberts and Frankel, 1950; Udenfriend, 1950).GABA is estimated to be the … incarnation\u0027s 7g

Anti-Choline Transporter Antibody from rabbit, purified by affinity …

Web1 de jan. de 2024 · Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters. ... As further shown in Figure 2 C, Ctrl fibroblasts, high-affinity (K 1 = 66.5 ± 8.5 μM) and low-affinity (K 2 = 299.0 ± 13.1 μM) Etn bindings were similar to COS-7 cells bindings ... Web20 de set. de 2024 · Choline is a positively charged quaternary ammonium compound that requires transporters to pass through the plasma membrane. Currently, there are three … Web1 de mai. de 2003 · High-affinity choline uptake (HACU) was one of the last features of cholinergic signaling to be defined at a molecular level, achieved through the cloning of … in county seats

IJMS Free Full-Text Molecular and Functional Analysis of Choline ...

WebGene ID: 104150095, updated on 24-Jan-2024. Summary Other designations. high affinity choline transporter 1-like, High affinity choline transporter 1, High affinity choline … WebHigh affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. AV41516. Anti-SLC22A1 (AB1) antibody produced in rabbit. IgG fraction of antiserum. in county numbersWeb103133831 - Gene ResultLOC103133831 high-affinity choline transporter 1-like [ (Amazon molly)] Gene provides a unified query environment for genes defined by … incarnation\u0027s 7m

"WebCholinergic neurons are crucial in learning and memory 1, 2, and cholinergic deficits are correlated with the severity of dementia 3. High-affinity choline uptake is the rate-limiting step in ... " - High affinity choline transporter 1-like

High affinity choline transporter 1-like

Web1 de jan. de 2005 · The transport of choline into neuronal terminals through the high-affinity choline uptake transporter (CHT) is essential for cholinergic transmission. Forebrain cholinergic systems have been shown ... Web1 de mar. de 2001 · High affinity choline transporter 1 Alternative names Hemicholinium-3-sensitive choline transporter ( CHT) Solute carrier family 5 member 7 Gene names …

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WebDOI: 10.1016/S0024-3205(03)00088-2 Corpus ID: 12543843; Expression of the high-affinity choline transporter CHT1 in epithelia. @article{Pfeil2003ExpressionOT, title={Expression of the high-affinity choline transporter CHT1 in epithelia.}, author={Uwe Pfeil and Rainer Viktor Haberberger and Katrin Susanne Lips and Lars Eberling and … WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Web3.24.2.2.2 Choline transport and metabolism to phospholipids. The lifetime of choline in the blood and its distribution in the body, as well as its transport into the cells are critical steps in the metabolic fate of choline. There are several transporter genes encoding choline transporters (Michel et al., 2006 ): (1) The high-affinity choline ... WebThe high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic terminals.CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.Although the substrate choline and …

WebFrom substrate specificity to promiscuity: hybrid ABC transporters for osmoprotectants WebCorpus ID: 40114318; Troxonium-like inhibitors of the high affinity uptake of choline in mouse brain synaptosomes in vitro. @article{Lindborg1984TroxoniumlikeIO, title={Troxonium-like inhibitors of the high affinity uptake of choline in mouse brain synaptosomes in vitro.}, author={Bjoern Gunnar Lindborg and Kristina Crona and …

Web1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ...

WebIn cholinergic neurons, high-affinity choline uptake in presynaptic terminals is the rate-limiting step in acetylcholine synthesis. Using information provided by the … in county orange spasWeb29 de jul. de 2014 · The cho-1 was shown to be expressed in the cholinergic motor neurons of the ventral nerve cord in C. elegans supporting the idea that cho-1 encodes the high-affinity choline transporter . The DNA sequence of cho-1 enabled him to clone homologous cDNAs in rat and human being , which were termed as CHT1. incarnation\u0027s 7kWeb2 de abr. de 2012 · Choline transporter-like protein 1 (CTL1) and CTL2 mRNA were highly expressed, while mRNA for high-affinity choline transporter 1 (CHT1) and organic cation transporters ... in county taxesWebCholine Transporter. Choline transporter-like proteins 1 (CDw92 is a C-terminal variant), 2 and 4 are expressed at the plasma membrane of neurons, endothelial cells, and … in county registrationWeb22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a high affinity for choline. The second is organic cationic transporters OCT1 and OCT2 that have low affinity for choline, which recognize many cationic substances, and are mainly … incarnation\u0027s 7n in courage definitionWeb1 de mar. de 2001 · Description. A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. in county list