High affinity copper uptake protein

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August undefined, 2024

WebThese high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The … WebLOC108023471 high affinity copper uptake protein 1 [] Gene ID: 108023471, updated on 15-Oct-2024. Summary Other designations. high affinity ...

SLC31A1 Antibody (CPTC-SLC31A1-1) - DSHB

WebHuman CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here we report the 6 … Web1 de abr. de 2014 · As previously mentioned, high-affinity Fe uptake at the plasma membrane depends in S. cerevisiae on Fet3 ferroxidase, which uses Cu as an indispensable cofactor for its activity. Therefore, Cu deficiency leads to impaired Fe transport in yeast, and consequently to multiple Fe-related symptoms [ 61 ]. biogeography definition example

High affinity copper uptake protein 1 DrugBank Online

High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais WebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like Web16 de mar. de 2010 · Copper and iron are essential elements employed in pathways that are conserved in all kingdoms of life. In eukaryotes, several interdependent connections between copper and iron homeostasis have been described previously ().For example, high-affinity iron uptake in Saccharomyces cerevisiae is mediated by multicopper … biogeolomloe.weebly.com

Tmac1, a transcription factor which regulated high affinity copper ...

X-ray structures of the high-affinity copper transporter Ctr1

WebWe ascertain the ability of these proteins to functionally complement and transport copper in the corresponding Saccharomyces cerevisiae high-affinity copper transport mutant. The specific expression pattern of the Arabidopsis COPT1–5 mRNA in different tissues was analyzed by RT-PCR. Webencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the biogeography evolution evidenceWebLOC106158117 high affinity copper uptake protein 1 [] Gene ID: 106158117, updated on 12-Aug-2024. Summary Other designations. high affinity ... biogeography examples animals

"WebCTR1, high affinity copper uptake protein 1; ATP7A, copper-transporting ATPase 1; CCO, cytochrome C oxidase; ATOX1, copper transport protein ATOX1; KRAS, Kirsten rat sarcoma 2 viral oncogene homolog. Display full size. Figure 1. KRAS-driven colorectal cancer (CRC) cells are addicted to copper metabolism. " - High affinity copper uptake protein

High affinity copper uptake protein

The SLC31 (Ctr) copper transporter family - PubMed

WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … Web1 de abr. de 2024 · The CTR1 gene of Saccharomyces cerevisiae encodes a protein required for high affinity copper uptake. The protein is expressed on the plasma membrane, is heavily glycosylated with O-linkages, and ...

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WebChimera protein of High affinity copper uptake protein 1 and Soluble cytochrome b562COPPER (I) IONZINC ION NCBI National Center forBiotechnology Information Search 6M98: Crystal structure of the high-affinity copper transporter Ctr1 in complex with Cu(I) Biological Unit for 6M98: trimeric; determined by author and by software (PISA)

WebProtein target information for High affinity copper uptake protein 1 (Norway rat). Find diseases associated with this biological target and compounds tested against it in … WebHigh affinity copper uptake protein 1 DrugBank Online with DrugBank on your side. High affinity copper uptake protein 1 Details Name High affinity copper uptake …

WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function Web5 de jun. de 2001 · Copper serves as an essential cofactor for a variety of proteins in all living organisms. Previously, we described a human gene (CTR1;SLC31A1)that encodes a high-affinity copper-uptake protein and hypothesized that this protein is required for copper delivery to mammalian cells.

Web5 de jun. de 2001 · Previously, we described a human gene (CTR1;SLC31A1) that encodes a high-affinity copper-uptake protein and hypothesized that this protein is required for …

Webalthough the role of Ctr1 internalization in copper uptake is currently unclear. Furthermore, exposure of yeast cells to high copper concentrations ($10 mM) triggers the degradation of Ctr1 at the plasma membrane in a mechanism that is inde-pendent of endocytosis and vacuolar proteases (14). The Ctr1 and Ctr3 high affinity copper transport ... daily amount of sugar for kidsWeb30 de mar. de 2024 · Functional assays revealed that it stimulates the initial rate of radiolabeled copper uptake. CTR1 transports copper with high affinity in a time-dependent and saturable manner and is copper-specific. Transport is an energy-independent process and is stimulated by extracellular acidic pH and high K+ … daily amount of sodium/saltWeb30 de dez. de 2005 · High affinity copper binding by wild type PrP has been confirmed by the independent techniques indicating the presence of specific tight copper binding sites … biogeolearningWebHigh CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer. Gene silencing of either CTR1 or DMT1 did not affect copper … biogeography shows that all camelsWebAlternate Antibody Name: Alternate Gene Names: Solute Carrier Family 31 (Copper Transporter), Member 1; COPT1; CTR1; Copper Transporter 1; Solute Carrier Family 31 … daily amount of sugar for womenWeb10 de abr. de 2024 · Abstract Heavy metal contamination impacts plant growth and productivity by causing damage at all levels of plant organization, making it one of the most significant abiotic stressors. This study evaluated the uptake and distribution of cadmium (Cd) and copper (Cu) in Solanum lycopersicum L. and identified the antioxidant enzyme … biogeography of time partitioning in mammalsWebhigh-affinity copper uptake (17, 18). Based on its copper-transporting function in a yeast assay, its sequence similarity to the yeast high-affinity copper uptake protein, and its ubiquitous expression, we hypothesized that CTR1 is required for copper uptake in mammalian cells (4). Indeed two recent studies, involving 64Cu uptake (19) and ... daily amount of sugar daily