Human interferon alpha
WebThe human IFN-α family comprises 13 genes encoding 12 proteins, with IFN-α13 being identical to IFN-α1. All IFN-αs bind to a common heterodimer receptor IFNAR1/IFNAR2. … WebTarget: Human interferon-alpha 2 (IFN-α2) Specificity: Reacts with human IFN-α1, IFN-α2, IFN-α5, IFN-α8, IFN-α14, IFN-α16, IFN-α17 and IFN-α21. Very weakly reacts with …
Human interferon alpha
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WebIFN-α treatment had a double and specifi c association with the HLA system (Mantel-Haenszel X c 2=4.706, p<0.05). CONCLUSIONS: Th is case report suggests that HLA system examination is an important and promising diagnostic aspect that may be considered in order to evaluate the appearance of thyroid disorders during the IFN-α treatment for Web21 mrt. 2024 · These findings have implications for the increased lethality of emerging variants and highlight the interferon subtypes that may be most successful in the treatment of early infections.Author Summary: In less than 2 years since its spillover into humans, SARS-CoV-2 has infected over 220 million people, causing over 4.5 million COVID-19 …
WebMentioning: 8 - The interaction between two human interferons alpha (IFN-αs) and the extracellular (EC) domain of human type I IFN receptor subunit 2 (IFNAR2) was analyzed. Previous experiments using Daudi cells showed that IFN-α21b and some IFN-α hybrids (made from IFN-α2c and 21b) competed poorly for the IFN-α2b binding site. This study … Web4 apr. 2024 · He and his colleagues treated four people with low-grade lymphomatoid granulomatosis with interferon alfa-2b over a 5-year period, and the treatment eradicated all signs of the disease in three of ...
WebThese data suggest that increased IFN-alpha8 activity may promote the loss of T cells by accelerating cell turnover and activation-induced cell death while decreasing the renewal of T cells by inhibiting the proliferative effect of IL-7. IFN-alpha8 and -alpha10 most potently enhanced expression of IFN-gamma, IL-2, and IL-4. WebSynthetic interferons (IFNs) are used in the treatment of several types of cancer. In addition to an antitumor effect, IFNs show antiangiogenic activity. The aim of this study was to …
WebWe will test your sample(s) and provide results for the following biomarkers:IFN-α-2, IFN-β, IFN-ε, IFN-γ, IFN-γ Receptor 1, IFNλ1, IFNλ2, IFNλ3, IFNω.Discovery Price $22.99/sample (single analysis)Single analysis (Tissue Homogenate/Cell Culture/Other)Minimum volume required: 50 uLPreferred volume: 75 uLDuplicate analysis (Tissue Homogenate/Cell …
WebIFN-α 起源于淋巴细胞组织并且在治疗各种人类肿瘤和病毒引起的疾病中有治疗性应用价值。. 天然产生和合成基因的重组 IFN-α 均能结合常见的细胞表面受体，并能诱导各种细胞系 … good topics to write about for research paperWeb15 sep. 2024 · Croze et al. (1996) performed immunoprecipitation studies demonstrating that the IFNAR2 gene, termed IFNAR2.2 by them, is present on Daudi cells as a cell surface protein of approximately 90 to 100 kD, which is tyrosine-phosphorylated and associated with IFNAR1 upon stimulation of cells with IFN-beta, rather than IFN-alpha. Platanias et al. … good topics to write about fantasyWebInterferon alfacon-1 (Infergen, Intermune) is a recombinant IFN-α that was developed based on a comparison of the sequences of the naturally derived human IFN-α's and … good topics to write about pyschologyWebIFN-alpha 1 is secreted by immune (lymphocytes, NK cells, B-cells and T-cells, macrophages) and non-immune cells (fibroblasts, endothelial cells, osteoblasts and others) in answer to a viral infection. The main function of the IFN-alpha 1 is to alert the organism in case of viral infection by detection of abnormal double stranded DNA, but also ... good topics to write about in gamingWebInterferons (IFNs) appear both locally and systematically early after viral infection and participate in limiting the spread of infection. They also affect cell differentiation, growth, … good topics to write about informative essayWebDermatophagoides farinae Extract Induces Interleukin 33-Mediated Atopic Skin Inflammation via Activation of RIP1 good topics to write about freelancingWeb19 jan. 2024 · Taken together, these studies support the model of Genin et al. in which activated IRF3 alone induces expression of conserved IFNα subtypes ( Figure 4C ), and … good topics to write about in psychology